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何薇薇
发布时间：2015-10-09   访问次数:26032   作者:



何薇薇，博士

副教授,博导

电话：021-64252293

E-mail:  heweiwei@ecust.edu.cn

地址：上海市徐汇区梅陇路130号实验十八楼1219室；邮编：200237

  

个人简历：

2007年6月毕业于中国科学技术大学，获硕士学位，从事生物化学及结构生物学研究；随后赴美，2013年2月毕业于美国Scripps研究所，获博士学位，从事神经肌肉萎缩症的分子生物学机制研究。2014年7月加入yl34511线路中心，任副教授。2015年入选上海市浦江人才计划。作为项目负责人，主持了国家自然科学基金（青年，面上），并参与科技部“973计划”（青年项目）,国家自然科学基金国际(地区)合作与交流项目,NSFC-云南联合基金重点支持项目。

  

研究方向：

致力于活性小分子特别是天然产物靶点识别与机制研究。


利用表观活性良好的天然产物作为工具，

（1）研究与癌症等疾病密切相关的细胞周期、自噬、代谢、蛋白相分离等生命过程；
（2）阐释分子机制，揭示疾病发生发展机制，发现生物学事件及其关联的契机；
（3）发展具有潜在治疗意义的小分子调控剂。



  

代表性论文：

  

1. Gongcai Lan, Jie Zhang, Wenbo Ye, Fan Yang, Ang Li*, Weiwei He*& Wei-Dong Zhang* Celastrol as a tool for the study of the biological events of metabolic diseases. SCIENCE CHINA Chemistry, 2019, 62(4), 409–416.

2. Zhongyin Zhang, Jinxin Wang, Jian Li, Fan Yang, Guodu Liu, Wenjun Tang, Weiwei He, Jian-Jun Fu, Yun-Heng Shen*, Ang Li*, and Wei-Dong Zhang* Total Synthesis and Stereochemical Assignment of Delavatine A: Rh-Catalyzed Asymmetric Hydrogenation of Indene-Type Tetrasubstituted Olefins and Kinetic Resolution through Pd-Catalyzed Triflamide-Directed C–H Olefination. J. Am. Chem. Soc. 2017, 139 (15), 5558–5567.

3. Jinpeng Pei, Shupeng Zhou, Fan Yang, Yu Sun, Ang Li*, Wei-Dong Zhang*,  and Weiwei He*, Identification and mechanistic studies of a  cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics.  Chem. Asian J. 2016, 11, 2715–2718.

4. Zhongyin Zhang, Fan Yang, Jian-Jun Fu,  Yun-Heng Shen*, Weiwei He* and Wei-Dong Zhang*, Delavatine A, a  structurally unusual cyclopenta[de] isoquinoline alkaloid from  Incarvillea delavayi, RSC advances, 2016, 6, 65885–65888.

5. Litao Sun, Ana Cristina  Gomes, Weiwei  He, Huihao  Zhou, Xiaoyun Wang, David W. Pan, Paul  Schimmel, Tao Pan*, and Xiang-lei  Yang*,Evolutionary gain of alanine mischarging to non-cognate  tRNAs with a G4:U69 base pair. J Am Chem Soc. 2016, 138(39), 12948–12955.

6. Weiwei He§, Ge Bai§,  Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi,  Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina  Guergueltcheva, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff* and  Xiang-Lei Yang* (§these authors contribute equally), CMT2D neuropathy is linked  to the neomorphic binding activity of glycyl-tRNA synthetase.  Nature, 2015, 526(7575), 710–714.

7. Rongcai Yue, Xia Li, Bingyang Chen,  Jing Zhao, Weiwei He, Hu Yuan, Xing Yuan, Na Gao, Guozhen Wu,  Huizi Jin, Lei Shan*, Weidong Zhang*, Astragaloside IV attenuates  glutamate-induced neurotoxicity in PC12 cells through Raf-MEK-ERK  pathway. PLOS ONE, 2015, 10(5):e0126603.

8. Xinhui Tian, Li Li, Xin Fang, Jianping  Zhang, Jinpeng Pei, Weiwei He, Lei Shan, Yunheng Shen and  Weidong Zhang, (−)- and (+)-Merrilliaquinone, a pair of new quinone enantiomers  from Illicium merrillianum and their distinctive cytotoxic effect on human  hepatoma cells. RSC Advances, 2015, 5, 75857–75862.

9. Min Chul Park, Taehee Kang, Da Jin,  Jung Min Han, Sang Bum Kim, Yun Jung Park, Kiwon Cho, Young Woo Park, Min Guo,  Weiwei He, Xiang-Lei Yang, Paul Schimmel, and Sunghoon Kim*,  Secreted human glycyl-tRNA synthetase implicated in defense against  ERK-activated tumorigenesis. PNAS Plus  2012, doi/10.1073/pnas.1200194109.

10. Weiwei He§, Hui-Min  Zhang§, Yeeting E. Chong, Min Guo, Alan G. Marshall, and Xiang-Lei Yang*(§these  authors contribute equally), Dispersed disease-causing neomorphic mutations on a  single protein promote the same localized conformational  opening. Proc. Natl. Acad. Sci. USA, 2011, 108, 12307–12312.