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洪鸣凰
发布时间：2018-10-22   访问次数:9975   作者:洪鸣凰

副研究员

联系信息

  • 办公室:实验十八楼333

  • Email: mhhong@ecust.edu.cn

  • 电话: +86 21 6425 2579

  • 传真: +86 21 6425 3406

教育经历

  • 2009.06 复旦大学yl34511线路中心 理学博士

  • 2004.06  复旦大学yl34511线路中心 理学学士

工作经历

  • 2014.01-今       yl34511线路中心  副研究员

  • 2010.08-2013.12    上海医药工业研究院  副研究员

  • 2009.07-2010.07  上海开拓者医药发展有限公司 研究员

研究方向

第一部分  工业药学——处方前研究和制剂学研究

研究方向：1. 药物晶型研究，包括晶型筛选、盐型筛选、共晶、离子液体、固态表征及质量标准制定

                    2. 固体药物制剂开发

                    3. 制剂研发中的晶型问题，包括制剂中药用晶型的判定、晶型转化及质量标准

第二部分 基础研究——肿瘤靶向纳米载药系统

研究方向：以纳米载药系统（包括脂质体、纳米粒、非粒子表面活性剂泡囊和共轭物）为载体，将抗肿瘤药物递送至肿瘤部位而实现靶向治疗。

发表文章

  1. Hao Wu, Zhaizhu Deng, Bijian Zhou, Minghui Qi, Minghuang Hong⁎, Guobin Ren⁎. Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties, J. Mol. Liq., 2019, 283:399-409.

  2. Minghuang Hong, Sai Guo, Kai Wang, Lei Ma⁎, Guobin Ren⁎, Influence factor investigation on the solution-mediated polymorphic transformation of Baricitinib phosphate, Z. Anorg. Allg. Chem., 2018, 644:849-855.

  3. Minghuang Hong#, Jingyan Chen#, Hui Zhou, Hao Xu, Guobin Ren⁎, Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate, Cryst. Res. Technol., 2017, 52(6): 1700045.

  4. Minghuang Hong#, Shiwang Wu#, Minghui Qi, Guobin Ren⁎, Solubility correlation and thermodynamic analysis of two forms of metaxalone in different pure solvents, Fluid Phase Equilib., 2016, 409: 1-6.

  5. Ming-Hui Qi#, Ming-Huang Hong#, Yan Liu, En-Fu Wang, Fu-Zheng Ren, Guo-Bin Ren⁎, Estimating thermodynamic stability relationship of polymorphs of sofosbuvir, Cryst. Growth Des., 2015, 15(10): 5062-5067.

  6. Minghuang Hong#, Lehui Xu#, Guobin Ren⁎, Jinyao Chen, Minghui Qi, Solubility of lansoprazole in different solvents, Fluid Phase Equilib., 2012, 331: 18-25.

  7. Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, Chang Sun, Chao Fang, Bin Shi, and Yuanying Pei⁎, Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles, J Control Release, 2010, 141: 22-29.

  8. Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, and Yuanying Pei⁎, Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin, J Control Release,2009,133, 96-102.

  9. Guo-Bin Ren⁎, Ming-Huang Hong, Jia-Liang Zhong, Dong-Xu Yi, Le-Hui Xu, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate, Acta Cryst., 2011, E67: o270.

  10. Saijie Zhu, Minghuang Hong, Guotao Tang, Lili Qian, Jiayuan Lin, Yanyan Jiang, and Yuanying Pei⁎, Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style, Biomaterials, 2010, 31: 1360-1371.

  11. Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang, Yanyan Jiang, and Yuanying Pei⁎, PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation, and in vivo tumor accumulation, Pharm. Res-Doror., 2010, 27: 161-173.

  12. Saijie Zhu, Minghuang Hong, Chen Liu, and Yuanying Pei⁎, Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation. Pharm. Dev. Technol., 2009, 14, 642-649.

  13. Jinju Ma, Ming-Hui Qi, Ming-Huang Hong, Jie Lu, Guo-Bin Ren⁎, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole propan-2-ol monosolvate: a second monoclinic polymorph, Acta Cryst., 2012, E68: o2017

  14. Yu-Feng Chen, Jin-Yao Chen, Ming-Huang Hong, Jie Lu, Guo-Bin Ren⁎, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate: a monoclinic polymorph, Acta Cryst., 2012, E68: o2015-o2016

  15. Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Longfei Guan, Xiajuan Huan, Shanshan Song, Jinxue He, Yingqing Wang, Yong Xi, Xinying Yang, Yanyan Shen, Yi Su, Yiming Sun, Yinglei Gao, Yi Chen, Jian Ding, Yun Tang, Guobin Ren, Zehong Miao, Jian Li⁎,Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy, Eur. J. Med. Chem., 2017, 138: 514-531

  16. Saijie Zhu, Lili Qian, Minghuang Hong, Lihong Zhang, Yuanying Pei, and Yanyan Jiang⁎, RGD-Modified PEG-PAMAM-DOX Conjugate: In vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor cells. Adv. Mater., 2011, 23: 84-89.

  17. Saijie Zhu, Rongqin Huang, Minghuang Hong, Yanyan Jiang, Zhuohan Hu, Chen Liu, Yuanying Pei⁎, Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur. J Pharm. Sci., 2009, 37: 573-580.