刁妍妍  工程师

个人简介：

       女，1987年9月出生，工程师，yl34511线路中心在职博士研究生。主要研究方向为药物设计方法学、先导化合物发现及结构优化。目前已发表SCI论文18篇，总计被引用197次，其中以第一及共同第一作者发表SCI论文8篇（含药物化学领域权威期刊《J. Med. Chem》3篇，IF=6.253）；已申请化合物发明专利10余项，获授权专利4项（含瑞士专利1项），其中DHODH抑制剂相关专利已完成成果转化。作为项目骨干，参与国家重点研发计划课题1项、“重大新药创制”国家科技重大专项1项。硕士毕业论文于2014年获上海市研究生优秀成果（学位论文）奖。

教育经历：

1. 2016.9-至今  ylzz总站线路检测 yl34511线路中心  博士研究生（在职）

2. 2009.9-2012.3  ylzz总站线路检测 yl34511线路中心  硕士研究生

3. 2005.9-2009.6  青岛科技大学 化工学院  本科生

工作经历：

1. 2012.7-至今  ylzz总站线路检测 yl34511线路中心  工程师

代表论文：

1. Yanyan Diao, Feng Hu, Zihao Shen, Honglin Li*. MacFrag: segmenting large-scale molecules to obtain diverse fragments with high qualities. Bioinformatics, 2023. 39(1) : btad012

2. Dou Dou#, Yanyan Diao# (共一作), Wenjie Sha#, Rongrong Su, Linjiang Tong, Wenjie Li, Limin Leng, Lijuan Xie, Zhixiao Yu, Haoming Song, Zihao Shen, Lili Zhu, Zhenjiang Zhao, Hua Xie, Zhuo Chen*, Honglin Li*, Yufang Xu*. Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK). J. Med. Chem., 2022. 65(3) : 2694–2709

3. Yanyan Diao, XiaoyuFang, PeiranSong, MengzhenLai, LinjiangTong, YongjiaHao, DouDou, YingqiangLiu, JianDing, ZhenjiangZhao*, HuaXie*, HonglinLi*, Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton’s tyrosine kinase inhibitors, Bioorg. Med. Chem., 2019, 27(15) : 3390-3395

4.  Yanyan Diao, Jing Jiang, Shoude Zhang, Shiliang Li, Lei Shan, Jin Huang, Weidong Zhang, Honglin Li*. Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening. Front. Chem., 2018, 6, 140

5.  Junsheng Zhu#, Le Han#, Yanyan Diao# (共一作), Xiaoli Ren, Minghao Xu, Liu-Xin Xu, Shiliang li, Qiang Li, Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian*, and Honglin Li*. Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole-Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem., 2015, 58(3), 1123-1139

6.  Minghao Xu#, Junsheng Zhu#, Yanyan Diao#(共一作), Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J. Med. Chem., 2013, 56 (20), 7911–7924

7.  Yanyan Diao, Weiqiang Lu, Huangtao Jin, Junsheng Zhu, Le Han, Minghao Xu, Rui Gao, Xu Shen, Zhenjiang Zhao, Xiaofeng Liu, Yufang Xu, Jin Huang*, and Honglin Li*. Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening. J. Med. Chem., 2012, 55, 8341-8349